Bstfa

Updated July 3, 2026

Overview

Product sourcing insights & recommendations

25 来源

Product Overview: BSTFA (CAS 25561-30-2)

N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) is a high-performance silylation reagent widely recognized for its "excellent" efficiency in analytical chemistry and organic synthesis Sigmaaldrich Wikipedia. It is a colorless, moisture-sensitive liquid that serves as a vital tool for converting polar compounds into volatile derivatives Researchgate Enamine.

* Primary Function: BSTFA replaces active hydrogen atoms (in -OH, -NH2, -COOH groups) with trimethylsilyl (TMS) groups, significantly increasing the volatility and thermal stability of the target molecules Restek Enamine.

* Key Advantage: Unlike common reagents like BSA, BSTFA reacts to form N-methyltrifluoroacetamide, which is highly volatile and does not interfere with Gas Chromatography (GC) detector signals Sigmaaldrich Restek.

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Market Trends & Insights (2025–2034)

The global BSTFA market is entering a phase of steady expansion, driven by the increasing complexity of pharmaceutical drug synthesis and the growth of high-precision analytical testing Datainsightsmarket Promarketreports.

#### 1. Market Size & Growth Forecast

* Current Valuation: The market was valued at approximately $19 million to $145 million in 2025 (depending on market scope definitions) Datainsightsmarket Promarketreports.

* Projected Growth: A CAGR of 4.2% to 7.1% is expected through 2033/2034, with high-end projections suggesting a market reach of over $22 billion in broad chemical intermediate categories Datainsightsmarket Promarketreports Linkedin.

#### 2. Key Sector Drivers

* Pharmaceutical Dominance: BSTFA is primarily used to protect sensitive functional groups during the production of Active Pharmaceutical Ingredients (APIs) Datainsightsmarket.

* Environmental & Food Safety: Rising global standards for detecting pollutants and food contaminants have surged demand for GC-MS derivatization reagents Promarketreports Beehiiv.

* Material Science Innovation: Newer applications include using BSTFA to impart hydrophobicity and chemical resistance to advanced coatings and polymers Promarketreports.

#### 3. Regional & Competitive Landscape

* Asia-Pacific Momentum: China and India are emerging as dominant production and consumption hubs due to their massive pharmaceutical manufacturing bases Linkedin Promarketreports.

* Top Players: The market is led by specialized chemical manufacturers such as Quzhou Ruilijie Chemical (holding ~25–30% share), Regis Technologies, and Solarbio Datainsightsmarket Promarketreports.

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Sourcing Intelligence

Current B2B listings indicate a price range of $32–$68 per bottle (Scientific Research grade) for small quantities, with bulk industrial orders available at significantly lower rates Alibaba Alibaba. Detailed supplier lists and product specifications are available in the attached sourcing files.

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Sources & References

25 sources cited · Verified industry data & reports

N,O-Bis(trimethylsilyl)trifluoroacetamide derivatization ...

Sigma-Aldrich

N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, ...

BSTFA

Wikipedia

N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) is an organosilicon compound. It is a colorless liquid that is very sensitive to traces of water or alcohols.

Regisil® BSTFA + 1% TMCS (RC-2)

Regis Chromatography

Regis Technologies manufactures BSTFA, a silyation reagent, for its Gas Chromatography Derivatization line.

BSTFA

Enamine

BSTFA is a widely used reagent for trimethylsilylation 1 . It converts active hydrogen-containing groups (such as acids, alcohols, thiols, and amines)

Silylation Derivatization Reagent, BSTFA w/1% TMCS (N,O ...

Restek

Silylation is the most widely used derivatization procedure for sample analysis by GC. In silylation, an active hydrogen is replaced by an alkylsilyl group.

Safety Data Sheet: BSTFA

Carl ROTH

1.1. Product identifier. Identification of the substance. N,O-Bis(trimethylsilyl)-trifluoroacetamide ≥98. %, for gas chromatography. Article number.