Cisco 4221
Overview
Product sourcing insights & recommendations
I have completed a comprehensive analysis of the Cisco ISR 4221 product and market trends for 2026.
The ISR 4221 is currently in its End-of-Life (EOL) phase, with sales officially having ended in November 2023. While the device remains a popular and cost-effective choice in secondary B2B markets—with prices ranging from $350 to $870—the industry is actively migrating toward the Cisco Catalyst 8200L series. The Catalyst series offers superior throughput and native SD-WAN integration, making it the recommended successor for modern branch environments.
The attached report provides detailed lifecycle milestones, technical comparisons, and current market pricing to assist with your sourcing or migration strategy.
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Cisco Isr 4221 Router Price Availability
Products · Top picks & verified manufacturers
Original New ISR4221/K9 ISR 4000 Series Integrated Multi-service Router
Henan Juetai Information Technology Co., Ltd.🇨🇳CN5 yrs
ISR4221/K9 Router 100% Brand New 4221 Series Integrated Services Router ISR4221/K9
Beijing Skylink Technology Co., Ltd.🇨🇳CN13 yrs
ISR4221/K9 Brand New Original Network Routers ISR4000 Series Integrated Services Routers Gigabit Core Router ISR4221/K9
New Original ISR4221/K9 ISR4221-SEC/K9 ISR4221-AX/K9 Enterprise VPN Router 2GE 2NIM 8GFLASH 4GDRAM IPB
Zhengzhou Jinyukewei Network Technology Co., Ltd.🇨🇳CN4 yrs
Brand New ISR4221/K9 ISR 4221 Integrated Services Router (2GE 2NIM 8G Flash Memory 4G DRAM IPB) in Stock Made in China
Original 4000 Series Intergrated Service Router ISR4221/K9
Galaxy Deep Technology Co.,Ltd.🇨🇳CN4 yrs
Router ISR 4300 Series Router ISR4461-K9, 4451, 4431, 4351, 4331, 4321 and ISR4221 ISR1100 sealed New Original
Beijing Ruilian Far Tong Network Technology Co., Ltd.🇨🇳CN2 yrs
ISR4221-SEC/K9 Original with One Year Warranty 4000 Family Integrated Services Router
Beijing Baochuangchaorui Technology Co., Ltd.🇨🇳CN12 yrs
ISR4221/4321/4331/4351/4431/4451/4461-SEC/V/AX/K9 10Gb Router New Original
Beijing Fengzhan Jiaye Technology Co., Ltd.🇨🇳CN1 yr
ISR4221/K9 for San FranCis Co 4000 Family Integrated Services Router
Shenzhen Haixunyi Communication Technology Co., Ltd.🇨🇳CN4 yrs
CIS CO Enterprise Router ISR4321/K9
Shanghai Shuaiqi Network Technology Co., Ltd.🇨🇳CN7 yrsCIS CO Enterprise Router ISR4321/K9
Deep Dive · Full Report
Full Market Report
1 document · Live-fetched from source
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Sources & References
42 sources cited · Verified industry data & reports
Cisco 4000 Family Integrated Services Router Data Sheet
Cisco
The ISR 4221 has only one 1Gbps connection to the Route Processor. upgradable to up to 32 GB. fixed quantity of 8GB of flash memory. ● Two USB type A 2.0 ports ...
Cisco 4221 Integrated Services Router
Cisco Systems
4221 Integrated Services Router: Access product specifications, documents, downloads, Visio stencils, product images, and community content.
Cisco 4221 Integrated Services Router - SecureITStore.com
secureitstore.com
Cisco ISR 4221 with 2 onboard GE, 2 NIM slots, 1 ISC slot, 8 GB Flash Memory default, 4 GB DRAM default. List Price: $2,130.53 Our Price: $1,259.05
ISR4221/K9 Price | Cisco 4000 Router ISR Series
ORM Systems
Key features include two Gigabit Ethernet ports, two NIM expansion slots, 4 GB DRAM, 8 GB flash memory, hardware encryption, and an internal power supply.
Cisco 4000 Series Integrated Services Router Data Sheet
Zavod za sigurnost informacijskih sustava (ZSIS)
The Cisco 4000 Family contains six platforms: 4221 ISRs. ® Software-Defined WAN (SD-WAN) Table 4 lists the general product specifications for the Cisco 4000 ...
Cisco ISR4221-SEC/K9 Router Specs | PDF
Scribd
Key specs include 35-75Mbps throughput, 2 Ethernet ports, 1 SFP port, 4GB RAM, and 2 NIM slots. It provides security functions through its bundled licenses.