Ws 12 Cooling Agent

Updated October 6, 2026

Overview

Product sourcing insights & recommendations

27 来源

WS-12 ((1R, 2S, 5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide) is a high-potency synthetic cooling agent gaining significant market momentum as a superior alternative to traditional menthol Nih Nahanutri. Unlike menthol, WS-12 is virtually non-volatile, odorless, and tasteless, providing a powerful cooling impact primarily on the front of the tongue without bitter or burning side effects Nahanutri Handomchemicals.

Product Insights & Specifications

Potency: Offers one of the strongest initial cooling impacts with a significantly longer-lasting effect than WS-3 and WS-23 Nahanutri Handomchemicals.
Applications: Broadly used in food (chewing gum, mints), cosmetics (skin creams, shower gels), and pharmaceuticals (oral care, topical medications) Noncomedogenic Handomchemicals.
Formulation: Sparingly soluble in water but highly soluble in ethanol and propylene glycol; stable in high-temperature processing Nih Linkedin.

Market Trends & Demand

Growth Outlook: The market for WS-series cooling agents is projected to grow at a CAGR of 11.5% Linkedin.
Key Drivers: Rising consumer preference for "long-lasting freshness" and the industrial shift toward non-volatile coolants that do not interfere with other flavors or fragrances Handomchemicals.
Regional Dynamics: China dominates as the primary manufacturing hub, while the US market shows high demand in premium pharmaceuticals and high-end cosmetics Handomchemicals.

Sourcing & Pricing

Current B2B market data shows a range of high-purity (99.5%+) WS-12 options, primarily from Chinese suppliers like Shenzhen Hechuangyuan and Handom Chemicals Handomchemicals. Pricing typically ranges from $60 to $145 per kilogram depending on order volume and purity .

The following file contains a detailed shortlist of high-purity WS-12 products matching food and cosmetic grade requirements.

Based on these market findings, you can continue with:

Sources & References

27 sources cited · Verified industry data & reports

Ethyl Menthane Carboxamide - Noncomedogenic Skincare ...

noncomedogenic.co.za

WS-12 is utilized in topical medications, including muscle pain relievers and itch creams. Its cooling effect helps in diminishing the sensations of pain and ...

Foreverest Resources Ltd

TraceGains

WS-12 ((1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide) is a synthetic compound designed to deliver a cooling sensation across ...

A study on the WS Series Cooling Agent Market projecting ...

LinkedIn · Gumball Gurus

WS-12 is designed for high-temperature processing stability, while WS-15 provides a cooling effect with a slight bitterness, often used in ...

Enzo Life Sciences WS-12 (25mg). CAS: 68489-09-8

Fisher Scientific

Cooling agent. High-affinity TRPM8 (cold menthol receptor 1; CMR1) agonist. Has an EC50 value ~2'000 times lower than that of (-)-menthol (ALX-420-042).

Synthesis of Menthol Glycinates and Their Potential as ... - PMC

National Institutes of Health (NIH) | (.gov)

WS-3 and WS-5 are both shown to have stronger cooling effects than (−)-menthol, estimated to have 35 times more cooling effects than (−)-menthol.3

Thermal analysis of WS series cooling agent

ResearchGate

Objective: Evaluation of the safety of WS series cooling agents for cigarettes. Methods: In this paper, pyrolysis-gas chromatography-mass ...